Pyroptosis: A New Frontier in Kidney Diseases
نویسندگان
چکیده
منابع مشابه
MicroRNA: a new frontier in kidney and blood pressure research.
MicroRNA (miRNA) has emerged rapidly as a major new direction in many fields of research including kidney and blood pressure research. A mammalian genome encodes several hundred miRNAs. These miRNAs potentially regulate the expression of thousands of proteins. miRNA expression profiles differ substantially between the kidney and other organs as well as between kidney regions. miRNAs may be func...
متن کاملThe fire within: pyroptosis in the kidney.
THE HISTOPATHOLOGICAL CHANGES that typically occur upon ischemia-reperfusion injury (IRI) have long been referred to as acute tubular necrosis. With the detection of apoptosis as a prototype mechanism for programmed cell death, researchers have focused on this elegant caspase-dependent and nonimmunogenic cell death mechanism also in IRI–with very limited clinical success. Despite hundreds of re...
متن کاملPyroptosis
Injury and physical trauma may inflict accidental cell death, but we have come to realize during the past four decades that cells may also actively engage cell death when needed. These regulated cell death forms are intrinsically connected with human embryonic development, homeostatic maintenance and disease pathology. For instance, the human body is composed of approximately 10(14) cells, mill...
متن کاملHIF-1alpha and infectious diseases: a new frontier for the development of new therapies
The aim of this review is to show the significant role of HIF-1alpha in inflammatory and infectious diseases. Hypoxia is a physiological characteristic of a wide range of diseases from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, which control the protein stability of hypoxia-inducible factor alpha 1 (HIF-1alpha) transcription factors. When stabilized, ...
متن کاملCircular RNAs: a new frontier in the study of human diseases.
Circular RNAs (circRNAs) are recently discovered new endogenous non-coding RNAs and an area of much research activity. In addition to their potential as major gene regulators, reports are linking heterogeneous circRNA groups with many different human disorders, especially cancer. In this review, we focus on the rapidly advancing field of circRNAs that play a part in human diseases. We list tool...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2021
ISSN: 1942-0994,1942-0900
DOI: 10.1155/2021/6686617